Obstet Gynecol. 1998 May;91(5 Pt 1):750-6.
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Obstet Gynecol. 1998 May;91(5 Pt 1):750-6. Routine ultrasound screening in pregnancy and the children's subsequent neurologic development. Department of Obstetrics and Gynecology, Uppsala University, Sweden. To test the null hypothesis of no association between
ultrasound exposure in early fetal life and impaired neurologic
development in childhood.
Study of children age 8-9 years whose mothers participated
in a randomized controlled trial of ultrasound screening
during pregnancy in Sweden during 1985-1987. Of 4637
eligible singletons, 3265 (70%) were studied through a
questionnaire to their mothers. Assessment of neurologic
development was based on parents' report of their child's
speech and motor development. Behavioral disorders were
assessed by a ten-item parent scale. Analyses were performed
according to both assignment and ultrasound exposure. With a
sample size of 1600 children in each group, a two-sided
alpha of .05 and beta of .10, a risk ratio of less than 1.4
for the studied variables could not be detected. Delayed speech development was reported by 2.9% in the
screening group compared with 2.4% in the nonscreening group
(odds ratio [OR] 1.21; 95% confidence interval [CI] 0.79,
1.88). Similar prevalences were found when analysis was
according to ultrasound exposure (OR 1.19, 95% CI 0.78,
1.83). Delayed motor development was reported by 7.6% in the
screening group compared with 7.2% in the nonscreening group
(OR 1.05; 95% CI 0.81, 1.37). Corresponding figures for
ultrasound-exposed and -unexposed were 7.7% and 7.2%,
respectively (OR 1.08; 95% CI 0.83, 1.40). There also were
no significant differences in behavioral disorders between
screened and unscreened children or between exposed and
unexposed children, respectively, according to parents'
ratings. No significant difference in impaired neurologic
development between ultrasound-exposed and -unexposed
children was found in this study.
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