The body's immune system (Q3.1) generally produces antibodies to counter foreign antigens (e.g. viruses). There are some clinical condition characterised by the body producing antibodies against its own tissues autoimmune diseases. It is believed that these autoantibodies are triggered by the production of antibodies by the immune system to counter bacteria or viruses and that these antibodies by misfortune may also cross-react with the body's own tissues if part of their chemistry is similar to that of the virus or bacterium. Premature menopause can be associated with autoantibodies and appropriate investigations may, therefore, provide an explanation although they do not alter the management options.

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