How should infertility associated with PCOS be treated?

• Introduction
• Abortion
• Amenorrhoea
• Birth Control
• Bladder Symptoms
• Cancer in Women
• Childbirth
• Children and Teenagers
• Diet / Weight Loss
• Dysmenorrhoea
• Endometriosis
• Fibroids
• HRT
• Hirsutism
• Hysterectomy
• Infections
• Infertility
• Medication Drugs
• Menopause
• Menorrhagia
• Miscarriage
• Painful Sex
• Pap Smear Test
• PCOS
• Polycystic Ovaries
• Definition PCOS
• Causation
• Duration
• Prevalence
• Seriousness
• Hormone Changes
• Weight Changes
• Amenorrhea
• Amenorrhea Treatment
• Hirsutism
• Pelvic Pain
• Treatment
• PCOS Fertility Treatment
• Metformin
• Metformin & The Baby
• Surgical Treatment
• Contraception
• Support Groups
• Pelvic Pain
• PMS
• Postpartum
• Pregnancy
• Self Esteem
• Sexual Problems
• Vaginal Discharge
• Vaginal Prolapse
• Vulval Symptoms

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Authors

Filico Balen AH. Braat DDM. West C. Patel A. Jacobs HS.

Institution:

Dept of Reproductive Endocrinology, Cobbold Labs, Univ Coll Med School, The Middlesex Hospital, Mortimer Street,London W1N 8AA; United Kingdom.

Title:

Cumulative conception and live birth rates after the treatment of anovulatory infertility: Safety and efficacy of ovulation induction in 200 patients. (1994)

Source:

Human Reproduction. Vol 9(8) (pp563-1570), 1994.

Abstract:

An analysis was performed on the cumulative conception rates, cumulative live birth rates and adverse effects of ovulation induction in patients with anovulatory infertility attending a single unit over an 11-year period. A total of 200 patients were included, 103 with clomiphene -resistant polycystic ovary syndrome (PCOS), 77 with hypogonadotrophic hypogonadism (HH) and 20 with weight-related amenorrhoea (WRA). Ovulation induction was performed using a number of protocols in which pulsatile luteinizing hormone-releasing hormone was administered s.c. or i.v. and gonadotrophins human menopausal gonadotrophins or follicle-stimulating hormone) were administered i. M. The cumulative conception and live birth rates in the first course of therapy and after 12 cycles of treatment were, respectively, 73.2 and 62.4% in PCOS patients, 82.1 and 65.4% in the HH group and 95.0 and 85.3% in the WRA group. The miscarriage rates for all courses of treatment were 15.5% in PCOS patients, 22.9% in HH patients and 32.3% in WRA patients which resulted in cumulative live birth rates that were not significantly different. The median number of cycles and ovulations to achieve a pregnancy was 2 in all groups. The multiple pregnancy rate was significantly greater in women with PCOS (17.9%) than in women with HH (3.6%, P = 0.0052, 95% CI 5.12-23.36%) but not WRA (3.2%, P= 0.07, 95% CI 4.35-24.92%). The rate of multiple pregnancy fell after the introduction of monitoring by transvaginal ultrasound. Correction of anovulatory infertility by appropriately selected ovulation induction regimens results in cumulative conception and live birth rates indistinguishable from normal.

See Also:

PCOS - Polycystic Ovary Syndrome

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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

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