Authors:

Matkov TG. Zenni M. Sandlow J. Levine LA.

Institution:

Dr. L. A. Levine, Department of Urology, Rush-Presbyterian-St. Lukes Med Ctr, 1725 West Harrison, Chicago, IL 60612; United States.

Title:

Preoperative semen analysis as a predictor of seminal improvement following varicocelectomy (2001-3257).

Source:

Fertility and Sterility. Vol 75(1) (pp3-68), 2001.

Abstract:

Objectives:

To determine the predictive role of preoperative semen analysis on both seminal improvement and pregnancy rates following varicocelectomy.

Design:

Retrospective data analysis.

Setting:

Two academic medical "center" infertility clinics.

Patients:

One hundred ten consecutive patients who underwent varicocelectomies. Seminal improvement data were available for 84 patients, and pregnancy data were available for 58 patients.

Interventions:


Stratification of patients based on preoperative total motile sperm count (TM). Varicocelectomy was performed on all patients.

Main Outcome Measure(s):

TMs, pregnancy rates, and conception techniques following varicocelectomy of each preoperative group.

Results:

Men with mild to moderate oligoasthenospermia (TM<5 million) had significantly better seminal improvement following varicocelectomy. While preoperative stratification showed no difference in pregnancy rates (when assisted reproductive techniques were included), men who achieved a postoperative TM >20 million were more likely to achieve conception by less invasive techniques (natural and intrauterine insemination vs. in vitro fertilization [IVF]).

Conclusion(s):

Varicocelectomy may be the most cost-effective initial intervention in males with TM >5 million. Patients with TM<5 million and concomitant female factor infertility may be better initial candidates for IVF.

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