Clomiphene Citrate - Mode of Action in Ovulation Induction
Clomiphene citrate, although not a steroid (Q 2.9), has a biochemical configuration similar to that of oestrogens.
It modifies hypothalamic and pituitary activity by binding to oestrogen receptor sites (hormones).
The negative feedback effect of oestrogens from the ovaries (Figure 10.1) is blocked and the hypothalamus and pituitary gland assume a falsely low reading of oestrogen levels.
As a result, GnRH activity and also FSH and LH output from the pituitary are increased and this increases the drive stimulating the ovarian follicles and egg release.
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