Authors:
Czeizel AE. Rockenbauer M. Mosonyi A.
Institution
A.E. Czeizel, Torokvesz lejto 32, 1026 Budapest; Hungary.
Title
A population-based case-control teratologic study of acetylsalicylic acid treatments during pregnancy (2000-3229).
Source:
Pharmacoepidemiology and Drug Safety. Vol 9(3) (pp93-205), 2000.
Abstract:Objectives:
To study the human teratogenic potential of two acetylsalicylic acid (ASA) drugs ASA-100 mg and ASA-500 mg.
Design:
Pair analysis of cases with congenital abnormalities and matched healthy controls. Settings - The large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Subjects - 38,151 pregnant women who had newborn infants without any defects (population control group); 22,865 case pregnant women who had newborns or fetuses with congenital abnormalities and 812 patient controls who had offspring with Down syndrome.
Results:
In the case group073 (4.7%) and in the population control group505 (4.0%), while in the patient control group2 (6.4%) of the pregnant women were treated with ASA. The ASA-500 was the major group because 1050 (4.6%) case, 1471 (3.9%) population control and 50 (6.2%) patient control pregnant women had this treatment. The case-control pair analysis did not indicate a higher rate of any ASA treatments during 2-3 months of gestation, i.e. in the critical period for most major congenital abnormalities. Thus all three of our analyses, i.e. - (1) in matched case-control pairs; (2) the comparison of medically recorded ASA use in the total control group and subjects with congenital abnormalities; (3) the comparison of the occurrence of ASA treatment between the patient control group and subjects with congenital abnormalities.
Conclusion:
- Treatment with ASA drugs studied during pregnancy did not indicate a higher teratogenic risk to the fetus.
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- 14 Can infection cause recurrent miscarriage and would treatment help?
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- 20 After every miscarriage I become more depressed. Could this account for the problem?
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