Authors:
Ille Wramsby ML. Sten-Linder M. Bremme K.
Institution
Dr. M.L. Wramsby, Department of Woman and Child Health, Karolinska Institute, Box 140, 171 76 Stockholm; Sweden.
Title:
Primary habitual abortions are associated with high Frequency of Factor V Leiden mutation (2000-3324).
Source:
Fertility and Sterility. Vol 74(5) (pp87-991), 2000.
Abstract:
Objectives:
To analyze the prevalence of the mutation G1691A in factor V gene (Leiden mutation), of mutation C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, and of polymorphism in G20210A in the prothrombin gene in women with recurrent abortions; further, to identify a subgroup at higher risk of being carriers of these mutations.
Design:
Prospective case control evaluation.
Setting:
University clinic.
Patients:
Eighty-four women with 3 or more consecutive miscarriages were compared with 69 controls.
Interventions:
None.
Main Outcome Measure(s):
Polymerase chain reactions were performed to identify the mutations G1691A in factor V and C677T in MTHFR genes and the polymorphism G20210A in the prothrombin gene.
Results:
In women with primary habitual abortions, 27.8% carried the Leiden mutation. No difference was observed in the prevalence of mutation C677T in the MTHFR gene or in polymorphism G20210A in the prothrombin gene.
Conclusion(s):
The Leiden mutation may play a considerable role for women having primary recurrent abortions.
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