Authors
Rai R. Shlebak A. Cohen H. Backos M. Holmes Z. Marriott K. Regan L.
Institution
R. Rai, Dept. of Repro. Science and Medicine, Imperial College, School of Medicine at St Mary's, South Wharf Road, London W2 1PG; United Kingdom.
Title:
Factor V leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage (2001-3267).
Source:
Human Reproduction. Vol 16(5) (pp61-965), 2001.
Abstract:
Activated protein C (APC) resistance, both in its congenital form, due to the factor V Leiden mutation, and in its acquired form, are important risk factors for systemic venous thrombosis. In view of the suspected thrombotic aetiology of some cases of recurrent miscarriage, the prevalence of APC resistance was determined among 1111 consecutive Caucasian women with a history of either recurrent early miscarriage (three or more consecutive pregnancy losses at<12 weeks gestation; n = 904) or a history of at least one late miscarriage (>12 weeks gestation; n = 207). A control group of 150 parous Caucasian women with no previous history of adverse pregnancy outcome was also studied. Acquired APC resistance was significantly more common among both women with recurrent early miscarriage (8.8%: 80/904; P = 0.02) and those with late miscarriage (8.7%: 18/207; P = 0.04) compared with controls (3.3%: 5/150). In contrast, the Frequency of the factor V Leiden allele was similar among (i) women with recurrent early miscarriage (3.3%:60/1808; 58 heterozygotes and one homozygote), (ii) those with late miscarriage (3.9%:16/414; 14 heterozygotes and one homozygote) and (iii) the control group (4.0%:12/300; 12 heterozygotes). Acquired but not congenital APC resistance (due to the factor V Leiden mutation) is associated with both early and late miscarriage.
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- 1 What is a miscarriage information?
- 2 What are the different types of miscarriage information?
- 3 How accurate are pregnancy tests information?
- 4 What is a blighted ovum information?
- 5 I have had a hydatidiform mole. What is this?
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- 8 I am miscarrying. How should this be treated information?
- 9 What is meant by recurrent miscarriage information?
- 10 I have a problem with recurrent miscarriage. What is the chance of my next pregnancy being successful information?
- Q 12.11 Recurrent Miscarriage I have miscarried again. Why does this keep happening information?
- 12 What congenital problems might be associated with recurrent miscarriage and how could they be treated information?
- 13 What traumatic conditions can cause recurrent miscarriage and how can they be treated information?
- 14 Can infection cause recurrent miscarriage and would treatment help information?
- 15 Could a metabolic disorder cause recurrent miscarriage information?
- 16 Could a hormonal problem account for recurrent miscarriage and would hormone treatment help me information?
- 17 Could an autoimmune problem cause recurrent miscarriage and how could this be treated information?
- 18 Could a tumour cause recurrent miscarriage information?
- 19 What degenerative processes may be associated with recurrent miscarriage information?
- 20 After every miscarriage I become more depressed. Could this account for the problem information?
- 21 Is it always possible to explain recurrent miscarriage information?
- 22 I have a problem with recurrent miscarriage. What treatment is available to ensure that this does not happen again information?
- 23 What is an ectopic pregnancy information?
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- 26 How can an ectopic pregnancy be diagnosed information?
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