Can an autoimmune problem cause recurrent miscarriages?

Abstract:

Objectives:

To investigate whether a decrease in the values of protein C (PC), protein S (PS), antithrombin III (ATIII), factor XII (FXII), or factor XIII (FXIII) has predictive value for subsequent miscarriages.

Design:

Prospective study.

Setting:

Nagoya City University Medical School.

Patients:

A total of 536 patients with a history of two or more first-trimester miscarriages: Intervention(s): One hundred and twelve patients treated with low-dose aspirin were excluded from the analysis.

Main Outcome Measure(s):

The subsequent pregnancy outcome of 424 patients was compared for abnormal and normal levels of each parameter.

Results:

There were no differences in the subsequent miscarriage rates between abnormal and normal values of PC, PS, ATIII, and FXIII. However, the rate with abnormal FXII is significantly higher than that with normal FXII.

Conclusion(s):

A decrease in FXII (but not in PC, PS, ATIII, or FXIII) predicts subsequent miscarriage in patients with a history of first-trimester recurrent miscarriages. Copyright (C) 2001 American Society for Reproductive Medicine.

Please click on the required question.

• 1  What is a miscarriage information?
• 2  What are the different types of miscarriage information?
• 3  How accurate are pregnancy tests information?
• 4 What is a blighted ovum information?
• 5 I have had a hydatidiform mole. What is this?
• 6 Why did I have a spontaneous miscarriage information?
• 7 How frequently do miscarriages occur information?
• 8 I am miscarrying. How should this be treated information?
•  9 What is meant by recurrent miscarriage information?
• 10 I have a problem with recurrent miscarriage. What is the chance of my next pregnancy being successful information?
• Q 12.11 Recurrent Miscarriage I have miscarried again. Why does this keep happening information?
• 12 What congenital problems might be associated with recurrent miscarriage and how could they be treated information?
• 13 What traumatic conditions can cause recurrent miscarriage and how can they be treated information?
• 14 Can infection cause recurrent miscarriage and would treatment help information?
• 15 Could a metabolic disorder cause recurrent miscarriage information?
• 16 Could a hormonal problem account for recurrent miscarriage and would hormone treatment help me information?
• 17 Could an autoimmune problem cause recurrent miscarriage and how could this be treated information?
• 18 Could a tumour cause recurrent miscarriage information?
• 19 What degenerative processes may be associated with recurrent miscarriage information?
• 20 After every miscarriage I become more depressed. Could this account for the problem information?
• 21 Is it always possible to explain recurrent miscarriage information?
• 22 I have a problem with recurrent miscarriage. What treatment is available to ensure that this does not happen again information?
• 23 What is an ectopic pregnancy information?
• 24 How frequently do ectopic pregnancies occur information?
• 25 Why do ectopic pregnancies occur information?
• 26 How can an ectopic pregnancy be diagnosed information?
• 27 How can an ectopic pregnancy be treated information?
• 28 Where can I obtain more information information?
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