Acta Biomed. 2005 Apr;76(1):33-6
Single-dose methotrexate for ectopic pregnancy treatment: preliminary data.
Merisio C, Department of Gynecology, University of Parma, Parma, Italy. carla. Merisio@unipr. It BACKGROUND AND AIM OF THE WORK: Our purpose was to evaluate the efficacy of a single-dose of MTX for ectopic pregnancy treatment in a sample of patients carefully selected according to strict inclusion criteria.
11 patients that matched the inclusion criteria were enrolled. Beta-hCG at diagnosis averaged 1349 mIU/ml out of the 11 treated patients, 10 (90%) received a single dose of MTX and had a time of EP resolution averaging 27.3 days. The remaining patient received an additional dose of MTX, equal to the start dose, with a time resolution of 35 days. This study provides evidence of the efficacy of MTX in EP treatment, both as therapy and as a form of clinical management: the successful medical management of EP, defined as beta-hCG levels becoming negative after administration of one or more MTX doses, was obtained in all treated cases.
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