Authors:
Brill K. Norpoth T. Schnitker J. Albring M.
Institution
Medical Department, Pharmaceutical Division, Schering AG, Berlin; Germany.
Title:
Clinical experience with a modern low-dose oral contraceptive in almost 100,000 users (1991-2109e).
Source:
Contraception. Vol 43(2) (pp01-110), 1991.
Abstract:
Efficacy, cycle control, tolerance, and adverse events were studied in a clinical Phase IV study using a new progestogen, gestodene, in an amount of 75 mug combined with 30 mug ethinylestradiol. The study was performed as a multicenter trial in 96,000 patients over a period of 6 cycles. Half of the patients taking the new preparation were fist-time OC users, the other half switched from another OC. With regard to contraceptive efficacy, the life-table analysis showed a value of 0.032% for method failure and 0.114% for patient failure. The correspondent Pearl-Index is 0.062 and 0.22. The new drug was found acceptable by more than 90% of the women involved in the trial. Dysmenorrhea present in the 'switchers' mostly disappeared on the new OC, while body weight and blood pressure remained virtually unchanged. Thus, it can be concluded that blood pressure and body weight behaviour is similar to that seen with other low-dose OCs. The new combined pill offers excellent cycle stability and has a very favourable effect on dysmenorrhea. The number of clinically diagnosed thrombotic events documented in this study was 0.65 per 1000 woman-years (TWY) and does not exceed the range of events seen in groups of women using non-hormonal methods of contraception (Oxford-FPA study 0.4/TWY and RCGP study 0.8/TWY).
Please click on the required question.
- 1 What is an oral contraceptive?
- 2 How popular are oral contraceptive pills?
- 3 What are the benefits of the combined oral contraceptive pill?
- 4 Will the combined oral contraceptive pill improve my periods?
- 5 Could the combined oral contraceptive pill change my libido (sex drive)
- 6 What are the risks of taking combined oral contraceptive pills?
- 7 What side effects could I have whilst taking the combined oral contraceptive pill?
- 8 What is the effect of the combined oral contraceptive pill on body weight?
- 9 Will the combined oral contraceptive pill increase my vaginal discharge?
- 10 Does the combined oral contraceptive pill increase the chance of pelvic infections?
- 11 What is the relationship between the combined oral contraceptive pill and fibroids?
- 12 Could a combined oral contraceptive pill increase my blood pressure?
- 13 Do combined oral contraceptive pills have any effect on the blood?
- 14 What is the relationship between the combined oral contraceptive pill and thromboembolism?
- 15 What is the relationship between the combined oral contraceptive pill and heart attacks?
- 16 What is the relationship between the combined oral contraceptive pill and strokes?
- 17 Does the combined oral contraceptive pill affect the breasts?
- 18 Could I feel depressed as a result of taking the combined oral contraceptive pill?
- 19 What is the relationship between the combined oral contraceptive pill and cancer of the ovary?
- 20 What is the relationship between the combined oral contraceptive pill and cancer of the uterus?
- 21 What is the relationship between the combined oral contraceptive pill and cancer of the cervix?
- 22 What is the relationship between the combined oral contraceptive pill and cancer of the breast?
- 23 Family Planning Support Groups.
- 24 Support Groups.
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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
