Authors:

Bilotta P. Favilli S.

Institution

Stabilimenti Chimico-Farmaceutici, Dott. R. Ravasini and Cia. S. P. A., I-00184

Rome; Italy.

Title:

Clinical evaluation of a monophasic ethinylestradiol / desogestrel-containing oral contraceptive (1998-2109f).

Source:

Arzneimittel-Forschung. Vol 38(7) (pp32-934), 1988.

Abstract:

A multicenter trial was conducted in 267 centers in Italy to evaluate the efficacy, acceptability and safety of a monophasic oral contraceptive containing 30 mug ethinyl estradiol and 150 mug desogestrel (Marvelon (TM)) 13,290 women were followed up for a total of 74,967 cycles. No pregnancies due to method failure were reported and only three because of patient failure. Cycle control was good. There was a decrease in the occurrence of irregular cycles and in the duration and amount of menstrual bleeding; the incidence of break-through bleeding and spotting was low. No severe side effects occurred and the incidence of minor complaints was generally lower during treatment than in the pre-treatment cycle. Body weight and blood pressure were not significantly altered.






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