J Med Assoc Ga. 1995 Sep;84(7):320-2

The pill and gynecologic cancer: controversy and mystery prevail.

Sargent MA .

Mercer University School of Medicine, Macon, GA, USA. PIP: Physicians must understand the effects of oral contraceptives (OCs) on gynecologic cancers in order to properly address the fears and concerns of their patients. The largest study providing data on this topic was a case-control study of breast, ovarian, and endometrial cancer in US women 20-54 years old. When interpreting the results of such a study, the strengths and weaknesses of a retrospective case-control study must be considered and avoidance of subject and researcher bias must be addressed in the report. The statistical concept of relative risk quantifies the association between use of OCs and the risk of a cancer. A relative risk of 1.0 shows no difference, a risk of 0.5 shows a diminished risk, and one of 1.5 shows an increased risk. Current data show no increased risk of breast cancer associated with OC use, a beneficial effect on ovarian cancer (producing a 40% reduction in risk), a relative risk of 0.5 of endometrial cancer (another beneficial effect of OC use), and an unknown effect on cervical cancer because of all of the confounding variables (such as increased screening, the number of sexual partners, age at first coitus, and exposure to human papilloma virus).


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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

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