Authors:
Ngai SW. Yeung KCA. Lao T. Ho PC.
Institution:
Department Obstetrics and Gynaecolog, University of Hong Kong, Tsan Yuk Hospital, Hospital Road,Hong Kong; Hong Kong.
Title:
Oral misoprostol versus mifepristone for cervical dilatation before vacuum aspiration in first trimester nulliparous pregnancy: A double blind prospective randomised study (1996-1495).
Source:
British Journal of Obstetrics and Gynaecology. Vol 103(11) (pp120-1123), 1996.
Abstract:
Objectives:
To compare the effectiveness of oral misoprostol and mifepristone for cervical priming before first trimester termination of nulliparous pregnancy.
Design:
Prospective double blind randomised study.
Setting:
Department of Obstetrics and Gynaecology, University of Hong Kong. Participants - One hundred nulliparous women undergoing termination of pregnancy between 8 and 12 weeks of gestation were recruited for this prospective randomised trial. The women were allocated to either the oral misoprostol or mifepristone group. Subjects in misoprostol group were given placebo and misoprostol 400 mug 36 h and 12 h respectively before vacuum aspiration. Subjects in mifepristone group were given 200 mg mifepristone and placebo 36 h and 12 h respectively prior to operation.
Main Outcome Measures:
Baseline pre-operative cervical dilatation, the incidence of side effects, the amount of blood loss and duration of procedure.
Results:
There were no significant differences in the baseline cervical dilatation, incidence of side effects, amount of blood loss and duration of procedure.
Conclusions:
Misoprostol and mifepristone are of similar effectiveness for cervical priming prior to vacuum aspiration in nulliparous women. Misoprostol has additional advantages of-being widely available and inexpensive.
Please click on the required question.
- 1 What does the term abortion mean?
- 2 What are the legal criteria that permit doctors to terminate a pregnancy in the UK?
- 3 How could we tell if there is a substantial risk that if the child were born it would suffer from such physical abnormalities as to be seriously handicapped - e.g. Down Syndrome?
- 3A What is Tay Sachs and should we test for it?
- 4 How prevalent is pregnancy termination?
- 5 Why do unwanted pregnancies occur?
- 6 I think I may be pregnant and I do not want to have a baby now. What should I do?
- 7 Should I terminate my pregnancy for social reasons?
- 8 How can my pregnancy be terminated?
- 9 What does a suction (surgical) termination of pregnancy involve?
- 10 What is a medical abortion?
- 11 What will happen to me if I have a medical abortion?
- 12 How do medical and surgical pregnancy termination compare?
- 13 What are the chances of medical termination failing?
- 14 What are the risks of pregnancy termination?
- 15 Why is there debate about the ethics of pregnancy termination?
- 16 Support Groups.
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