PMS: How can my premenstrual syndrome be treated?

Pilot study of the efficacy and safety of a modified-release magnesium 250mg tablet (sincromag((r))) for the treatment of premenstrual syndrome.

Quaranta S,Buscaglia MA,Meroni MG,Colombo E,Cella S.

Unita Operativa Ostetricia e Ginecologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy.

Background:

Magnesium deficiency has been implicated as a possible contributing factor to some symptoms of premenstrual syndrome (PMS) and several studies have reported a lower intracellular magnesium concentration in women with PMS. Thus, it has been suggested that magnesium supplementation may improve certain symptoms in women with PMS.

Objectives:

This open-label study assessed the efficacy and safety of a patented modified-release magnesium 250mg tablet for improving symptoms in women affected by PMS.

Methods:

After a 3-month observational period, women aged 18-45 years with a regular menstrual cycle (from 25-35 days) who were affected by PMS (determined by a score of >/=25 points on a PMS questionnaire) [n = 41] were given the modified-release magnesium tablet over three menstrual cycles, beginning 20 days after the start of their last menstrual period and continuing until the start of their next menstrual period.

Results:

PMS symptoms improved during magnesium treatment. After 3 months, the mean total PMS score (primary endpoint), as assessed by the investigator using Moos' Modified Menstrual Distress Questionnaire, was significantly lower than before therapy (p< 0.0001). During the same period, the mean PMS scores, as recorded in patients' diaries (secondary efficacy variables), also showed significant improvements (p< 0.0001 for all subscales). The relative decreases in total PMS scores, as assessed by investigator and patient, were 35.1% and 33.5%, respectively. The magnesium tablet was well tolerated, with vertigo the only treatment-related adverse event reported (one patient).

Conclusions:

We concluded that modified-release magnesium was effective in reducing premenstrual symptoms in women with PMS in this preliminary study.

Please click on the required question.

• Premenstrual Syndrome - PMS What is The Premenstrual Syndrome (PMS)
• 2 How prevalent is PMS?
• 3 How can we tell if I have PMS?
• 4 How can my PMS be evaluated?
• 5 How can cyclical breast pain (mastalgia) be treated?
• 6 How can my PMS be treated?
• 7 What is the place of progestogens and progesterone in the management of PMS?
• 8 Could suppressing my menstrual cycle reduce my PMS problems?
• 9  Could a diuretic help my PMS?
• 10 Is there a place for anti-depressants or anxiolytic drugs in the management of PMS?
• 11 Is there a place for removing my ovaries in the management of PMS?
• 12 What can be done about my decreased libido (sex drive)
• 12A What is the place of Viagra (sildenafil citrate) in sexual dysfunction in women?
• 13 How is PMS treatment monitored?
• 14 How long should PMS treatment be taken?
• 15 What is the chronic fatigue syndrome?
• 16 What is seasonal affective disorder (SAD)
• 17 Where can I obtain more information?
• 18 Support Groups.

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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

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