Authors:
Gilmore DH. Hawthorn RJS. Hart DM.
Institution
Department of Gynecology, Stobhill General Hospital, Glasgow G21 3UW; United Kingdom.
Title:
Treatment of the premenstrual syndrome: A double blind placebo controlled cross over study using danazol (1989-430).
Source:
Journal of Obstetrics and Gynaecology. Vol 9(4) (pp18-322), 1989.
Abstract:
A double blind placebo controlled cross over study was conducted to assess the response of women with severe premenstrual syndrome to treatment with danazol. Daily self assessment of clinical state was measured using the Moos menstrual distress questionnaire. The data were analysed for the Moos symptoms clusters and the most prevalent individual symptoms using the Wilcoxon matched pairs test. Most of the common premenstrual symptoms improved to a statistically greater extent with danazol than with placebo. Despite the incidence of minor side effects danazol, 400 mg/day, proved to be an effective symptomatic treatment for the premenstrual syndrome and should be considered in the management of women with severe symptoms, or in those who are resistant to other forms of treatment.
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- Premenstrual Syndrome - PMS What is The Premenstrual Syndrome (PMS)
- 2 How prevalent is PMS?
- 3 How can we tell if I have PMS?
- 4 How can my PMS be evaluated?
- 5 How can cyclical breast pain (mastalgia) be treated?
- 6 How can my PMS be treated?
- 7 What is the place of progestogens and progesterone in the management of PMS?
- 8 Could suppressing my menstrual cycle reduce my PMS problems?
- 9 Could a diuretic help my PMS?
- 10 Is there a place for anti-depressants or anxiolytic drugs in the management of PMS?
- 11 Is there a place for removing my ovaries in the management of PMS?
- 12 What can be done about my decreased libido (sex drive)
- 12A What is the place of Viagra (sildenafil citrate) in sexual dysfunction in women?
- 13 How is PMS treatment monitored?
- 14 How long should PMS treatment be taken?
- 15 What is the chronic fatigue syndrome?
- 16 What is seasonal affective disorder (SAD)
- 17 Where can I obtain more information?
- 18 Support Groups.
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