Best Pract Res Clin Obstet Gynaecol. 2006 Dec 11;
Perimenopause and depression: strength of association, causal mechanisms and treatment recommendations.
Gyllstrom MEAuthors:
Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA. Perimenopause represents a significant transition in a woman's life. The evidence to support an association between perimenopause and depression is mixed, yet recent prospective studies have provided stronger evidence to support such an association. Interpretation of study data are complicated by methodological issues, such as a lack of standard definition for perimenopause or depression, reducing comparability. A variety of causal factors, including psychological, genetic and physiological, have been implicated in depression during perimenopause, which lends weight to a multifactorial model. Physicians should consider initiating dialogue about menopause and symptom relief at age 40 and screening perimenopausal women for depressive symptoms. Selective serotonin reuptake inhibitors are a first line of treatment for depression, but hormone therapy could be considered for women experiencing menopausal symptoms unless there are contraindications. Future research should focus on establishing temporality and studying these potential relationships among women of different ethnicities.
Please click on the required question.
- 1 What will happen to me at my menopause?
- 2 Why does nature put women through the menopause?
- 3 Is life-expectancy changing?
- 4 What happens to my reproductive hormones at the menopause?
- 5 What non-hormonal changes occur at the menopause?
- 6 What problems might I have as a result of my menopause?
- 7 When am I likely to reach my menopause?
- 8 What is a premature menopause?
- 9 What are hot flushes and will HRT reduce them?
- 10 What causes hot flushes and night sweats?
- 11 Can my bladder problems be related to the menopause?
- 12 Can the menopause be associated with psychological problems.
- 13 How long can my menopausal (climacteric) symptoms last?
- 14 Is there a test that will accurately determine when my menopause has occurred?
- 15 Is it normal to experience heavy periods before the menopause?
- 16 How are heavy periods around the time of the menopause treated?
- 17 Is there a need to investigate vaginal bleeding after the menopause (postmenopausal bleeding)?
- 18 What could be the cause of vaginal bleeding after the menopause?
- 19 What is atrophic vaginitis?
- 20 What local genital symptoms can be associated with the menopause?
- 21 I have gone through the menopause and now have some bleeding (postmenopausal bleeding PMB). What will my gynaecologist wish to do?
- 22 Could I have any other long-term medical problems resulting from my menopause?
- 23 What is coronary heart disease?
- 24 What is osteoporosis?
- 25 Where else can I obtain further information?
- 26 Could I have some recommended menopause support groups.
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