Urinary Incontinence: What surgical treatments are available for stress incontinence?

Eur Urol. 2006 Oct 20;

Efficacy and Tolerability of Tolterodine Extended Release in Male and Female Patients with Overactive Bladder.

Authors:

Dmochowski R ,Abrams P,Marschall-Kehrel D,Wang JT,Guan Z.

Vanderbilt University Medical Center, Nashville, TN, USA.

Objectives:

To evaluate the efficacy and tolerability of tolterodine extended release (ER) in men and women with overactive bladder (OAB).

Methods:

We analyzed data from two 12-wk, placebo-controlled trials of tolterodine ER (4mg QD). Patients completed 7-d bladder diaries and rated the urgency sensation associated with each micturition on a 5-point urgency rating scale. Micturitions were categorized by urgency rating: total (1-5), non-OAB (1-2), OAB (3-5), or severe OAB (4-5). Changes in micturitions during 24-h, daytime, and nocturnal intervals were assessed.

Results:

At baseline, 73% (547 of 745) of men and 57% (539 of 953) of women were continent. By week 12, tolterodine ER (n=848) reduced OAB and severe OAB micturitions during 24-h, daytime, and nocturnal intervals in both sexes compared with placebo (n=850). Adverse event rates were low and similar across treatment and gender.

Conclusions:

In men and women with OAB, tolterodine ER reduced OAB and severe OAB micturitions, and was well tolerated.

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