Genital Herpes

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Pediatr Infect Dis J. 1989 Jan;8(1):30-5.

Neonatal herpes simplex virus infection: a report of 43 patients. Koskiniemi M , Happonen JM , Jarvenpaa AL , Pettay O , Vaheri A .

Children's Hospital, University of Helsinki, Finland.

We present a series of 43 infants with neonatal herpes simplex virus infection treated at the Children's Hospital, University of Helsinki, during a 16-year period from 1970 to 1985. Twelve mothers (28%) had a history of genital herpes during pregnancy, and two had had labial herpes infection. Eight infants (19%) were delivered by cesarean section. In 14 (33%) infants symptoms appeared within 24 hours and in 26 (61%) they appeared within 7 days. The presenting symptoms were neurologic in 79%, cutaneous in 30%, respiratory in 19%, cyanosis/pallor/grayish skin in 16%, irritability in 12% and fever in 7%. Herpes simplex virus was detected most early and frequently in pharyngeal swabs, in one-third on Postnatal Days 2 to 5. Cerebrospinal fluid contained an increased amount of protein and/or pleocytosis in 72%. Abnormal electroencephalographic background activity appeared in 56% and electrical paroxysms in 41%. Six infants (14%) died, 9 (21%) were damaged severely and 6 (14%) were moderately or mildly damaged. Poor prognosis was associated with acute maternal illness at delivery, prematurity, visceral involvement and/or electrical paroxysms in the electroencephalograms. This study underlines the occurrence of intrauterine transmission of herpes virus, infections with neurologic manifestations, early symptomatology and the need for prompt diagnosis, brain biopsy in selected patients and antiviral therapy in neonates with herpes virus infection.

Please click on the required question.

• 1 What skin conditions may affect the vulva?
• 2 Which viral infections can affect the genitalia?
• 3 What problems can occur to people with herpes simplex?
• 4 What are genital warts?
• 5 What is lichen sclerosus?
• 6 How is lichen sclerosus treated?
• 7 What could be causing my vulval irritation?
• 8 How could my vulval irritation be treated?
• 9 What is a Bartholin's cyst / abscess?
• 10 How is a Bartholin's cyst / abscess treated?
• 11 What is vulvodynia?
• 12 How can my vulvodynia be treated?
• 13 What is vestibulitis?
• 14 How can my vestibulitis be treated?
• 15 Where can I obtain further information?
• 16 Support Groups.

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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

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