Evidence from the International Breast Cancer Trialists Collaborative Group have found that any woman with hormone sensitive breast cancer would benefit from tamoxifen regardless of her age or menopausal status. Tamoxifen has been shown to protect substantially against breast cancer recurrence and death. These conclusions were derived from a meta-analysis (Q33.23) of 55 trials involving 37,000 women. In the group of women with oestrogen sensitive tumours or those with unknown oestrogen sensitivity, there was a 47 % reduction in recurrence rate over ten years following five years of tamoxifen treatment. The survival rate was improved by 11 % over ten years. Tamoxifen was associated with a slight increase in the incidence of endometrial cancer.

Women's Health

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