The role of progesterone in human biology is discussed inQ 2.13 . Progestogens are synthetic chemicals that have actions similar to progesterone. Dydrogesterone (Duphaston - Solvay), medroxyprogesterone acetate (Provera Pharmacia and Upjohn) and norethisterone (Primolut N - Schering H.C. / Utovlan Searle) are commonly prescribed by themselves or in combination usually with an oestrogen. Other progestogens (including norgestrel, desogestrel, levonorgestrel and ethynodiol diacetate) are used in oral contraception (Table 16.2). Progesterone is available as suppositories / pessaries (Cyclogest - Shire), injection (Gestone - Ferring) and a vaginal gel (Crinone - Serono). There is a progesterone cream for application to the skin (Progest - progesterone replacment therapy).
Progesterone and progestogens may be employed in the management of:-
- infrequent periods (Q6.25).
- infertility
- contraception (Q14.5).
- menorrhagia (heavy periodsQ 24.17B).
- premenstrual syndrome (progesterone and progestogen in PMS).
- menopausal symptoms with hormone replacement therapy (HRT and progestogen).
- cancer (Q32.33D).
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