- Down-regulation is employed in IVF protocols (24) to ensure that there is no natural release of LH which could result in premature and unplanned release of eggs from the ovaries.
- Suppression of gonadotrophins by GnRH analogues is beneficial for pre-operative preparation for fibroid removal (17)
- and in the management of endometriosis (endometriosis).
- When administered in intermittent bolus by a pump, GnRH agonists are effective in inducing ovulation.
A new generation of GnRH antagonists is being produced and they are currently under investigation.
- These antagonists have only inhibitory effects so that they will not cause a flare response (Q33.5).
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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
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