DULOXETINE Hydrochloride (hcl)
Duloxetine (brand names Cymbalta,Yentreve) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic neuropathy and in some countries for stress urinary incontinence (SUI).
Indications
Moderate to severe stress urinary incontinence in women.
Stress urinary incontinence is involuntary loss of urine when the bladder comes under stress, e.g. from coughing, sneezing or other movements that increase the intra-abdominal pressure. Duloxetine was first reported to improve outcomes in SUI in 1998. Systematic reviews with meta-analysis, conducted in 2005 and 2008 (University of Minnesota), each found ten controlled trials. Both systematic reviews concluded that duloxetine did not lead to cure of stress urinary incontinence in the vast majority of people, but that episodes of incontinence were reduced by about 50%. This was associated with an improvement in quality of life measurements. Mild side effects were common, and about a fifth had to discontinue the medication because of poor tolerance.
Cautions
-
Please click on the required question.
Thank you for choosing to visit us.
This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
Your Own Web Presence
For £35
Have your own web ad on the internet and optimized for good positioning.
Your Own Dedicated Web Page Designed Specifically For You
More Effective
Than Your Own
Single Page Website
For £35