|
Am J Obstet Gynecol. 2007 Sep;197(3):223-8.
Maternal obesity and risk of stillbirth: a metaanalysis.
Chu SY, Kim SY, Lau J, Schmid CH, Dietz PM, Callaghan WM, Curtis KM.
Division of Reproductive Health, Centers for Disease Control and Prevention,
Atlanta, GA 30333, USA. syc1@cdc.gov
We conducted this metaanalysis to summarize the available epidemiologic
evidence on the relationship between maternal overweight and obesity and the
risk of stillbirth. We identified studies from 3 sources: (1) a PubMed
search of relevant articles that were published between January 1980 and
September 2005, (2) reference lists of publications that were selected from
the PubMed search, and (3) reference lists of review articles on obesity and
maternal outcomes that were published between 2000 and 2005. We used a
Bayesian random effects model to perform the metaanalysis and metaregression.
Nine studies were included in the metaanalysis. The unadjusted odds ratios
of a stillbirth were 1.47 (95% CI, 1.08-1.94) and 2.07 (95% CI, 1.59-2.74)
among overweight and obese pregnant women, respectively, compared with
normal-weight pregnant women. The metaregression analysis found no evidence
that these estimates were affected by selected study characteristics.
Maternal obesity is associated with an increased risk of stillbirth,
although the mechanisms to explain this association are not clear.
|
