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Eur J Obstet Gynecol Reprod Biol. 2008 Mar;137(1):21-6.
Pregnancy outcome in obese and morbidly obese gestational diabetic women.
Yogev Y, Langer O.
Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital
Center, University Hospital of Columbia University, New York, NY, USA.
Objectives:
We sought to determine whether pregnancy outcome differs between
obese and morbidly obese GDM patients and to assess pregnancy outcome in
association with mode of treatment and level of glycemic control. Methods:
A
cohort study of 4830 patients with gestational diabetes (GDM), treated in
the same center using the same diabetic protocol, was performed. Obesity was
defined as prepregnancy BMI >30 and <35kg/m(2); morbid obesity was defined
as prepregnancy BMI >/=35kg/m(2). Well-controlled GDM was defined as mean
blood glucose <105mg/dl. Pregnancy outcome measures included the rates of
large for gestational age (LGA) and macrosomic babies, metabolic
complications, the need for NICU admission and/or respiratory support, rate
of shoulder dystocia, and the rate of cesarean section. Results:
Among the
GDM patients, the rates of obesity and morbid obesity were 15.7% (760 out of
4830, BMI: 32.4+/-1.6kg/m(2)) and 11.6% (559 out of 4830, BMI:
42.6+/-2.2kg/m(2)), respectively. No differences were found with regard to
maternal age, ethnicity, gestational age at delivery or oral glucose
tolerance test (OGTT) results. Moreover, similar rates of cesarean section,
fetal macrosomia, shoulder dystocia, composite outcome, and metabolic
complications were noted. Insulin treatment was initiated for 62% of the
obese and 73% of the morbidly obese GDM patients (P<0.002). Similar rates of
obese and morbidly obese patients achieved desired levels of glycemic
control (63% versus 61%, respectively). In both obese and morbidly obese
patients who achieved a desired level of glycemic control (<105mg/dl), no
difference was found in pregnancy outcome except that both neonatal
metabolic complications and composite outcomes were more prevalent in
diet-treated subjects in comparison to insulin-treated GDM patients.
Conclusion:
In obese women with GDM, pregnancy outcome is compromised
regardless of the level of obesity or treatment modality.
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