How
should the woman with severe pre-eclampsia or eclampsia be
managed following delivery? |
Clinicians should be aware of the risk of late seizures and ensure that
women have a careful review
before discharge from hospital.
Anti-hypertensive medication should be continued after delivery as
dictated by the blood pressure. It
may be necessary to maintain treatment for up to 3 months, although most
women can have treatment
stopped before this.
Women with persisting hypertension and proteinuria at 6 weeks may have
renal disease and should be
considered for further investigation.
Clinicians should be aware that up to 44% of eclampsia occurs
postpartum, especially at term, so
women with signs or symptoms compatible with pre-eclampsia should be
carefully assessed.
Severe pre-eclampsia or eclampsia can occur in the postpartum period. Up
to 44% of eclampsia has
been reported to occur postnatally, especially in women presenting at
term.9401
Women who develop
hypertension or symptoms of pre-eclampsia postnatally (headaches,visual
disturbances,nausea and
vomiting or epigastric pain) should be referred for a specialist opinion
and investigation to exclude
pre-eclampsia.9802
Women who deliver with severe pre-eclampsia (or
eclampsia) should have
continued close observation postnatally. As eclampsia has been reported
up to 4 weeks postnatally,
the optimum length of inpatient postnatal stay is unclear but the
incidence of eclampsia and severe
pre-eclampsia falls after the fourth postpartum day.
The decision
about discharge from hospital
needs to take account of the risk of late seizures. Most women with
severe pre-eclampsia or
eclampsia will need inpatient care for 4 days or more following
delivery. Careful review to ensure
improving clinical signs is needed before discharge.
Anti-hypertensive therapy should be continued after delivery. Although,
initially, blood pressure
may fall, it usually rises again at around 24 hours postpartum. A
reduction in anti-hypertensive
therapy should be made in a stepwise fashion. There is no reason why the
woman cannot go home
on treatment, to be weaned off therapy as an outpatient. After pre-eclampsia,
blood pressure can
take up to 3 months to return to normal. During this time, blood
pressure should not be allowed
to exceed 160/110 mmHg. Currently, there is insufficient evidence to
recommend any particular
anti-hypertensive. However, it is good practice to avoid the use of
alpha methyldopa in the
postnatal period because of its adverse effect profile, particularly
depression. In breastfeeding
women, labetalol, atenolol, nifedipine and enalapril are currently in
use, either singly or in
combination.