Pregnancy Thromboprophylaxis
 

Pregnancy Thromboprophylaxis

    

Thromboprophylaxis in pregnancy and the puerperium

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PREGNANCY

THROMBOPROPHYLAXIS

 

Risk factors for thromboembolism

 

 

Am J Obstet Gynecol. 2008 Feb;198(2):233.e1-7. Epub 2007 Nov 12.

Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium--a register-based case-control study.
Jacobsen AF, Skjeldestad FE, Sandset PM.

Department of Obstetrics and Gynecology, Ulleval University Hospital Trust, Oslo, Norway. anneflem.jacobsen@ulleval.no

Objectives:

This study was undertaken to estimate the incidence of venous thromboembolism in pregnancy and puerperium and to identify risk factors for pregnancy-related venous thromboembolism.

Study Design:

A register-based case-control study with 613,232 pregnancies from 1990-2003 in 11 Norwegian counties. Medical records for eligible cases were revisited and relevant medical data were transferred to a specific case-report form. The diagnosis of venous thromboembolism was based on strict criteria. Data were analyzed by chi2 test and forward stepwise logistic regression.

Results:

In total, 615 cases were detected. The incidence of venous thromboembolism was 1 per 1000 pregnancies. The ante- and postnatal incidences were quite similar. Antenatal risk factors were assisted reproduction, gestational diabetes, age older than 35 years, multiple pregnancies, and primi-parity. Postnatal risk factors were cesarean section, preeclampsia, assisted reproduction, abruptio placenta, and placenta previa.

Conclusion:

We found different ante- and postnatal risk patterns. Assisted reproduction and gestational diabetes were significant antenatal risk factors; whereas cesarean section and preeclampsia were strong postnatal risk factors.

 

 

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