Infertility

Fertility can hinge on swimming conditions in the uterus

Fertility can depend upon swimming conditions in the uterus

For a mammal’s sperm to be successful, it must finish the swim of its life to reach and fertilize an egg. That’s simpler if it swims through water, not goo. It ends up that both the male and female have a role in making that take place. A Washington State University scientist has found that the uterus in female mice includes enzymes that can break down semen, making it less gel-like, more watery, and for that reason easier to swim in. Scientists have formerly believed semen is broken down by enzymes from the prostate gland. But writing today in the journal PLOS Genetics, Wipawee Winuthayanon, an assistant teacher in WSU’s School of Molecular Biosciences, reports that female mice also produce the enzyme, using estrogen to cause the process. They also saw that when a female mouse lacked a gene to make this occur, semen failed to liquefy in its uterus. “Our studies supply the very first proof of how the interaction between semen and the female reproductive tract might affect fertility,” the researchers write. The research study highlights an underappreciated issue in the physical changes that semen undergoes and the relative roles of secretions in both the male and female reproductive systems …
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Oral contraceptives reduce general well-being in healthy women

Contraceptive pills reduce basic well-being in healthy females

One of the most common combined oral contraceptive pills has a negative effect on females’s quality of life but does not increase depressive signs. This is shown by a major randomised, placebo-controlled research study carried out by researchers at Karolinska Institutet in Sweden in cooperation with the Stockholm School of Economics. The results have been published in the scientific journal Fertility and Sterility. “In spite of the fact that an estimated 100 million females worldwide use birth control pills we understand remarkably little today about the pill’s effect on females’s health. The scientific base is really limited as relates to the birth control pill’s effect on lifestyle and depression and there is a great requirement for randomised studies where it is compared with placebos,” states professor Angelica Lindén Hirschberg at the Department of Women’s and Kid’s Health at Karolinska Institutet. She has led just such a study together with Niklas Zethraeus, associate teacher at the Department of Learning, Informatics, Management and Ethics, Anna Dreber Almenberg from the Stockholm School of Economics, and Eva Ranehill of the University of Zürich. 340 healthy females aged in between 18 and 3 …
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Daylight savings time impacts miscarriage rates among select IVF patients, study finds

Daylight savings time impacts miscarriage rates among choose IVF clients, study finds

Daylight savings time (DST) adds to higher miscarriage rates amongst females undergoing in vitro fertilization (IVF) who had had a prior pregnancy loss according to brand-new research out of Boston Medical Center (BMC) and IVF New England. The findings, which are released online in the journal Chronobiology International, may shed light on the impact of circadian rhythm modifications on reproduction and fertility. Daytime cost savings time represents a subtle but widespread interruption to day-to-day circadian rhythms. The one-hour distinction has been previously reported to cause unfavorable health effects, such as increased instances of cardiac arrest, but little is known concerning its influence on fertility. “To our knowledge, there are no other studies looking at the impacts of daylight cost savings time and fertility results”, said Constance Liu, MD, PhD, a physician in the department of obstetrics and gynecology at Massachusetts General Hospital and matching author, who carried out the research during her residency at BMC. “We understood that we were researching an uncharted field, and it was important for us to comprehend the effect a one-hour modification had on patients undergoing IVF.” Researchers took a look at th …

See all stories on this subject Aspirin increases pregnancy rate in women with inflammation Infertility – largely specified as the failure to develop after 1 year of vulnerable sex – affects 1 in 8 couples in the United States. These couples have trouble either developing or keeping a pregnancy, with a third of infertility cases being credited to the female partner. The Centers for Illness Control and Avoidance (CDC) report that 12 percent of all U.S. females of reproductive age are unable to become pregnant. A few of these ladies may have chronic, low-grade swelling, which has been formerly associated with causes of infertility. New research study – performed by the Eunice Kennedy Shriver National Institute of Kid Health and Person Development (NICHD), a neighborhood of the National Institutes of Health (NIH) – examines the impacts of low-dose aspirin on pregnancy rate, pregnancy loss, births, and inflammation throughout pregnancy. The findings, published in The Journal of Scientific Endocrinology & Metabolism, suggest that a low everyday dose of aspirin may help women who have previously lost a pregnancy successfully carry a baby to term. Lindsey A. Sjaarda, Ph.D., who is a personnel scientist in the NICHD Department of Intramural and Population Health Research, is the stu …

Random process analysis could give a woman more information about which infertility treatment is best

Random procedure analysis might give a lady more info about which infertility treatment is best

It’s been used to study car cruise control systems and population development of certain animal species, and now scientists think Markov modeling might one day help a woman and her physician much better peruse infertility treatment choices. Markov modeling is a complex analysis process that in this case might be able to transform a series of pertinent truths – like a female’s age, body weight and AMH blood levels, which assist forecast the egg supply – into a more reasonable, actual time photo of how effective a particular infertility treatment will be for her, stated Dr. Arni S.R. Srinivasa Rao, a mathematical modeler in the Department of Biostatistics and Public health at the Medical College of Georgia at Augusta University. Unlike existing methods for providing insight on the success rate of a provided treatment, the Markov model offers a dynamic picture that can be constantly updated and quickly equated into a physician-friendly app, said Rao, corresponding author of the study in the journal Reproductive Sciences. Infertility treatment can often be a long-lasting, economically and mentally pricey procedure for ladies and their households. With numerous aspects causing infertility – some of w.

See all stories on this subject Offered drug may safeguard ovaries and fertility from damage by chemotherapies

A drug already used to slow tumor development might likewise prevent infertility caused by standard chemotherapies, inning accordance with a study in mice published online in the Proceedings of the National Academy of Sciences. Led by researchers from NYU Langone Medical Center, the study discovered that the drug everolimus safeguards ovaries from cyclophosphamide, a chemotherapy used typically against breast cancer, but understood to diminish the supply of egg cells had to accomplish pregnancy. Female mice treated with everolimus, in addition to chemotherapy, were discovered to have more than two times as many offspring afterward as mice treated with the chemotherapy alone. Such strong results with an available drug, state the research study authors, might speed the procedure of making an application for consent to test it in premenopausal cancer patients. “Our outcomes argue that everolimus might represent a fertility-sparing drug treatment to match the freezing of eggs and embryos, which are valued methods, but time-consuming, costly, less efficient with age, and not protective of long-lasting ovarian function,” states very first research study author and NYU Langone reproductive endocrinologist Kara Goldman, MD. Following a four-year residency in obstetrics and gyneco …

Treating polycystic ovary syndrome early may help prevent later drop in fertility

Treating polycystic ovary syndrome early might assist prevent later on drop in fertility

In teen women with polycystic ovary syndrome (PCOS), bringing the quantity of abdominal visceral fat and liver fat down to regular restores ovulation, stabilizes the symptoms of androgen excess, and might help avoid future subfertility, new research from Spain suggests. The results of the study were presented at ENDO 2017, the annual conference of the Endocrine Society, in Orlando. “PCOS is extremely widespread in adolescent ladies and women of reproductive age and is a prime cause of female subfertility,” said lead author Lourdes Ibáñez, M.D., Ph.D., professor of pediatrics at the Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, in Barcelona, Spain. “While no treatment is certified for PCOS, approximately 98 percent of ladies who have it, whether or not they are sexually active, take a combined oral contraceptive tablet that contains an estrogen and a progestagen,” said Ibáñez. “If SPIOMET? the low-dose combination of an anti-androgen plus two insulin-sensitizers? can restore ovulation rates after lowering ectopic fat, later subfertility can potentially be prevented in numerous ladies who nowadays depend upon costly and time-consuming fertility strategies to conceive,” she said. In a.

See all stories on this subject Successful reversal of Vasalgel male contraceptive in rabbits Outcomes of a research study of a promising brand-new male contraceptive called VasalgelTM were published in Standard and Scientific Andrology. The polymer gel is injected into the vas deferens and obstructs the passage of sperm. The research study followed the development of seven rabbits effectively contracepted for an average of 14 months before the gel was eliminated. Sperm flow returned in all animals after turnaround, validating unblocked sperm transit (patency of the vas deferens) and requiring ongoing development of this item. When considering reproductive control, couples frequently count on female contraceptive methods, consisting of everyday pills and long-acting products such as IUDs and implants. However, many women can not endure the side effects of hormonally-based contraceptives and grow disappointed with the downsides of other methods. Guy who wish to control their own reproduction or lift the concern of contraception from their partners have even less choices. No new male contraceptives have emerged in more than a century, and guys need to depend on the old standbys: prophylactics, which are essential for lowering the occurrence of sexually transferred infections in new relationships but lead to high pregnancy rat …
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Technology to screen embryos before implantation falls short

Technology to screen embryos before implantation fails

The healthy development of an embryo developed through in vitro fertilization (IVF) depends upon whether the majority of, if not all, of the cells have the proper variety of chromosomes. With pre-implantation genetic screening (PGS) innovation, medical professionals can, in principle, spot-check chromosome count before selecting which embryo to implant in the mom. In a new article, nevertheless, scholars at Brown University and the University of Washington report that PGS has severe restrictions that can just be gotten rid of with more human embryo research study, even as they acknowledge the controversy surrounding that research study. What physicians and hopeful moms and dads want to see in PGS is 46 chromosomes – 2 sets of 23 – a typical state of affairs called “euploidy.” An unusual number, or “aneuploidy,” might signal a fatal defect in early development. In 2013 in the United States, more than 15 percent of IVF pregnancies ended in miscarriage, typically due to the fact that of aneuploidy, wrote Dr. Eli Adashi, teacher of medical science and previous dean of medicine and life sciences at Brown, and Rajiv McCoy, a genome sciences postdoctoral fellow at Washington. The miscarriage rate increases rapidly with maternal age, as does the rate of aneupl …
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