What's missing from current methods for genetic screening of sperm donors?

Exactly what’s missing from present approaches for hereditary screening of sperm donors?U.S. sperm banks perform genetic testing to screen for and disqualify providers of a restricted number of recessive illness anomalies, but more thorough and inexpensive DNA-based screening methods are now available that can detect much more disease-causing genetic variations. To secure future kids from extremely heritable diseases, sperm banks need to modernize their testing methods, according to an article published in Hereditary Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is readily available for download on the Hereditary Testing and Molecular Biomarkers website. In the article “Carrier Screening is a Deficient Strategy for Identifying Sperm Donor Eligibility and Minimizing Danger of Disease in Receiver Kid,”Ari Silver, Jessica Larson, Maxwell Silver, Regine Lim, Carlos Borroto, Brett Spurrier, Anne Morriss, and Lee Silver, Gene Peeks, Inc. (Cambridge, MA and New York, NY )and Princeton University(Princeton, NJ), compared the outcomes of DNA-based screening of sperm donors using three business carrier-testing panels versus next generation DNA sequencing (NGS) technology. Whereas each carrier panel can recognize serious …
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Why fraternal twins run in families

If a lady’s female family members have fraternal twins, she is more likely to give birth to twins herself, but the genes behind this phenomenon have stayed a secret. Now, researchers reporting April 28 in the American Journal of Human Genes have pin down two genes related to twinning. They reveal genetic links between having twins and female production of, and response to, follicle-stimulating hormonal agent, which might help anticipate how some women react to infertility treatments. “There’s an enormous interest in twins, and in why some females have twins while others do not,” says Dorret Boomsma, a biological psychologist at Vrije Universiteit (VU) Amsterdam who has assembled one of the biggest twin databases in the world. “The concern is really basic, and our research shows for the first time that we can recognize hereditary variants that contribute to this likelihood.” Boomsma and a worldwide team of researchers aggregated hereditary data from twin databases in the Netherlands, Australia, and the US. The sample completed 1,980 moms of fraternal (or “dizygotic”) twins developed without fertility treatments and 12,953 controls. The scientists were looking for genetic variants, shared …
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