Eur J Obstet Gynecol Reprod Biol. 2006 May 9;


Clinical aspects and luteal phase assessment in patients with recurrent vulvovaginal candida.

Spacek J,Buchta V,Jilek P,Forstl M.

Department of Obstetrics and Gynaecology, University Hospital, Sokolska 581, Hradec Kralove 500 05, Czech Republic.


This study was undertaken to characterize the patients with recurrent vulvovaginal candida.

Study Design:

Basic data of personal history and history of recurrent vulvovaginal candida, lower genital tract symptoms and signs in 50 patients were analyzed in this longitudinal follow-up study including the determination of midluteal serum progesterone and urinary pregnanediol levels during the luteal phase in 84 cycles (recurrent vulvovaginal candida) and 60 cycles (healthy controls).


All patients suffered primary idiopathic form of recurrent vulvovaginal candida. Frequently, there was a striking discrepancy between severe symptoms and clinical finding, which was often negligible or normal. There was no redness and no or minimum discharge in 52% of culture documented attacks. In contrast to the healthy controls, the patients had significantly lower levels of progesterone (p<0.01) as well as those of urinary pregnanediol (p<0.05).


Culture positive attacks in patients with recurrent vulvovaginal candida represented rather a form of vulvovaginal discomfort than attacks of vulvovaginal candida with typical inflammatory changes. Significantly lower progesterone levels in the RVVC patients as compared to the healthy controls suggest a link between an altered hormonal status and one of possible causes of RVVC in these women.

Women's Health

Thank you for choosing to visit us.

This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.

David Viniker retired from active clinical practice in 2012.
In 1999, he setup this website - - to provide detailed
information many of his patients requested. The website attracts thousands of visitors every day from around the world.
If you would like advice on how to make more from your website, please visit his website Keyword SEO PRO or email him on

David Viniker Linkedin Profile