Roth AC. Milsom I. Forssman L. Wahlen P.


Department of Obstetrics and Gynaecology, University of Goteborg, Goteborg; Sweden.


Intermittent prophylactic treatment of recurrent vaginal candida by postmenstrual application of a 500 mg clotrimazole vaginal tablet (1990-2040d).


Genitourinary Medicine. Vol 66(5) (pp57-360), 1990.


The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candida. The number of episodes of acute vulvovaginal candida experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recurrence Frequency after 6 months intermittent prophylaxis with clotrimazole (30.3%) was lower (p<0.001) than that recorded for the women who received placebo (79.3%). After an additional 6 months observation period without treatment there was no significant difference in the cumulative recurrence Frequency between the groups (clotrimazole 84.9%; placebo 86.2%). The vagina was recolonised with Candida albicans in 70% of the women after 6 months prophylactic treatment with clotrimazole and in 86% of the women who had received placebo. Thus, this study has demonstrated that postmenstrual prophylactic treatment with a single 500 mg clotrimazole vaginal tablet, applied monthly, prevents recurrence of symptoms, although it does not eliminate yeasts from the vagina.

Women's Health

Thank you for choosing to visit us.

This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.

David Viniker retired from active clinical practice in 2012.
In 1999, he setup this website - - to provide detailed
information many of his patients requested. The website attracts thousands of visitors every day from around the world.
If you would like advice on how to make more from your website, please visit his website Keyword SEO PRO or email him on

David Viniker Linkedin Profile