Authors:

Wyatt KM. Dimmock PW. Jones PW. O'Brien PMS.

Institution:

Dr. K. M. Wyatt, Academic Dept. Obstetrics Gynaecol., North Staffordshire

Hospital, Stoke on Trent ST4 6QG; United Kingdom. E-Mail:

Meal10@keele. Ac.uk.

Title:

Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: Systematic review. (1999 2662)

Source:

BMJ. Vol 318(7195) (pp375-1381), 1999.

Abstract:

Objective. To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design. Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects. Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures. Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo.

Results:

Odds ratio relative to placebo for an improvement in over-all premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients.

Conclusion:

Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.


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