Med Hypotheses. 1990 Apr;31(4):323-7.

The aetiology of premenstrual syndrome is with the progesterone receptors.

Dalton K.

Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are widely distributed in target cells throughout the body (1, 2, 3, 4, 5, 6, 7). It suggests also why measuring P blood levels is of no value in PMS (8, 9, 10, 11); why pharmacological doses of P are required (8); and explains the failure of current double blind trials using low dose P (12, 13, 14, 15, 16).


 

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This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.

David Viniker retired from active clinical practice in 2012.
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