Authors:

Di Carlo C. Palomba S. Tommaselli GA. Guida M. Di Spiezio Sardo A. Nappi C.

Institution:

Dr. C. Di Carlo, Clinica Ostetrica/Ginecologica, Via S. Pansini 5, 80131 Naples; Italy.

Title

Use of leuprolide acetate plus tibolone in the treatment of severe premenstrual syndrome (2001-3261).

Source:

Fertility and Sterility. Vol 75(2) (pp80-384), 2001.

Abstract:

Objectives:

To evaluate the effectiveness of GnRH agonist (GnRH-a) plus tibolone in the treatment of severe premenstrual syndrome (PMS).

Design:

Prospective, double-blind, placebo-controlled clinical trial.

Setting:

Department of Obstetrics and Gynecology, University of Naples 'Federico II,' Naples, Italy.

Patients:

Thirty patients affected by severe PMS, aged 23-29 years (mean age +/- SD, 25.3 +/- 2.9 years). Intervention(s): Treatment for two cycles with leuprolide acetate depot (3.75 mg IM for 28 days) in association with tibolone (2.5 mg/d orally) or placebo (1 tablet per day orally).

Main Outcome Measure(s):

The mean severity of each symptom and sign of PMS was evaluated using a visual analog scale during the last 7 days of each treatment cycle in comparison with the last 7 days of the cycle before treatment.

Results:

Mean scores for each of the adverse psychological/physical and positive psychological symptoms were significantly improved during treatment. No statistically significant difference was detected between patients treated with tibolone and placebo. A significantly lower number of hot flushes per day was observed in groups treated with GnRH-a and tibolone in comparison with GnRH-a and placebo.

Conclusion(s):

Tibolone administered in association with GnRH-a does not reduce the therapeutic effect of GnRH-a in women affected by PMS. Tibolone used in association with GnRH-a may provide long-term medical treatment for women with PMS. Copyright (copyright) 2001 American Society for Reproductive Medicine.

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This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
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