Study sheds light on how ovarian cancer spreads

Research study clarifies how ovarian cancer spreads

With 20,000 medical diagnoses each year, ovarian cancer is the ninth most common cancer and fifth leading cause of cancer death among females in the United States. So many ladies pass away from ovarian cancer since it frequently goes undiscovered till it has spread out within the pelvis and abdomen, by which point it is challenging to treat and usually fatal. A team of scientists from the University of California, Riverside and the University of Notre Dame are studying the molecular mechanisms by which ovarian cancer spreads – or metastasizes – to uncover new therapeutic opportunities. In their most current paper, published in the journal Oncogene, they used live imaging and electron microscopy to study the cellular activities connected with effective metastasis, consisting of the expression of a group of proteins called cadherins, which help cells bind together. Since these proteins allow cancer cells to anchor to brand-new sites in the body, it may be possible to interrupt transition by blocking cadherin-mediated binding. The research study was led by Mark Alber, a prominent professor of applied mathematics at UC Riverside, and M. Sharon Stack, a Kleiderer-Pezold teacher of biochemistry and director of Notre Dame Harpe …
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